While filming Dead to Me, Christina Applegate laments the end of her acting career and her “excruciating pain.”

Christina Applegate, best known for her role in the hit comedy “Married… with Children,” has made the painful decision to retire from acting due to the difficulties created by her multiple sclerosis (MS) disease.

Applegate, who has been open about her health issues, revealed her MS diagnosis publicly in 2021, shining a light on her ongoing battle with the neurological condition.

The 51-year-old actress spoke openly about her choice to withdraw behind the camera at the recent Variety TV FYC Fest, highlighting the significance of her Hollywood Walk of Fame ceremony.

She expressed gratitude for the presence of her co-stars from her most recent project, “Dead to Me,” including Linda Cardellini and Liz Feldman, as well as her former colleagues from the iconic show “Married… with Children,” including Katey Sagal and David Faustino, on this momentous occasion.

Applegate underlined the significance of having them by her side, representing both the beginning and, potentially, the end of her acting career.

During the ceremony, Applegate hinted that “Dead to Me” would be her final film, which she confirmed at the SAG Awards.

In an interview with Variety, she expressed enormous joy with her final performance, calling it a lifelong dream come true.

Applegate’s excellent cooperation with Linda Cardellini on “Dead to Me” earned her three Primetime Emmy nominations and a Golden Globe nomination for the show’s final season, which circulated.

Reflecting on her experience, she expressed doubt about her future as an actress, wondering how she would deal with her condition’s physical demands and limits on future sets.

After learning of her condition, she also praised the actors and crew of the Netflix series for their sympathy and understanding.

“Who will be as kind and understanding as this remarkable group of people was?” Applegate questioned if she would find the same degree of support elsewhere.

Applegate bravely expressed her discomfort while filming, admitting it was visible in the final product. She stated a desire to shelter herself from revisiting the enormous sorrow she had on set as the mother of her 12-year-old daughter, Sadie Grace, whom she shares with her husband, Martyn LeNoble.

Despite this, Applegate remained enthusiastic about the project, finding solace in the fact that the show’s creator, Liz Feldman, saw her promise as an actress.

While her on-screen presence may diminish, she remains dedicated to delivering outstanding performances behind the scenes.

Applegate’s eyes light up with excitement as she talks about her upcoming voice-over gigs, which she describes as “one of the coolest things I’ve ever done.”

She also intends to move into production and hopes to establish a podcast with a friend who suffers from MS. These activities allow her to explore new possibilities while managing her health condition.

In prior articles, the actress detailed her typical symptoms, including sleeplessness, numbness, and tingling in her limbs—all indicators of MS. Walking without a walking stick has become increasingly difficult for her. She has accepted it as part of her “new normal.”

Multiple sclerosis predominantly affects the brain and spinal cord and often appears between the ages of 30 and 50, with a higher frequency in women. Although the illness is rarely fatal, it remains a devastating influence throughout one’s life.

Christina Applegate remains inspirational despite the difficulties and physical constraints imposed by her MS. Her decision to leave acting, combined with her drive to pursue other creative endeavors, displays tenacity in the face of adversity.

As she begins a new chapter in her life, her unrelenting devotion to providing exceptional performances shines brightly, even if it is off-screen.